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Prostate Cancer
Treatment Guide™

Treatment
Description
Prostate Cancer
Patient Profile
Prostate Cancer
Treatments
Prostate Cancer
Survival Rates
Prostate Cancer
Side Effects
Therapy News View Procedures Share Your Experience

Hormone
Therapy

Prostate Hormone Therapy

Prostate hormone therapy suppresses, blocks, or eliminates testosterone to slow the tumor’s growth. Prostate Hormone
Therapy

Prostate hormone therapy suppresses, blocks, or eliminates testosterone to slow the tumor’s growth.

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Hormone Therapy Uses

Therapy can slow the tumor’s growth or lower a PSA level; it may be used before, during, or after other treatment. Hormone Therapy Uses

Therapy can slow the tumor’s growth or lower a PSA level; it may be used before, during, or after other treatment.

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Shrinking the Prostate

Surgical castration patients return home the day of the surgery. Treatment is given orally or by injection. Shrinking the Prostate

Surgical castration patients return home the day of the surgery. Treatment is given orally or by injection.

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Hormone
Therapy Effects

Hormone therapy does not destroy cancer but research has shown effectiveness in enhancing other treatments. Hormone
Therapy Effects

Hormone therapy does not destroy cancer but research has shown effectiveness in enhancing other treatments.

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Hormone Therapy
Side Effects

May cause impotence, weight gain, hot flashes, fatigue, loss of muscle mass; and hormone “flare” in LHRH use. Hormone Therapy
Side Effects

May cause impotence, weight gain, hot flashes, fatigue, loss of muscle mass; and hormone “flare” in LHRH use.

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Prostate News

Click here for the latest news on Hormone Therapy.Prostate News

Click here for the latest news on Hormone Therapy.

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Hormone Therapy
Videos

Click here to view Hormone Therapy procedures. Hormone Therapy
Videos

Click here to view Hormone Therapy procedures.

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Hormone Therapy
Experiences


Click here to share your Hormone Therapy experiences.Hormone Therapy
Experiences

Click here to share your Hormone Therapy experiences.

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Brachytherapy

Chemotherapy

Cryotherapy & Cryosurgery

Radiation
Therapy

Prostatectomy

Robotic Prostatectomy

Watchful
Waiting

Complementary
and
Alternative Medicine

High Intensity
Focused
Ultrasound (HIFU)

Emerging Technologies

 

Results of Treating Prostate Cancer with Hormone Therapy

“Pamidronate to Prevent Bone Loss During Androgen-Deprivation Therapy for Prostate Cancer”
Matthew R. Smith, M.D., Ph.D., Francis J. McGovern, M.D., Anthony L. Zietman, M.D., Mary Anne Fallon, L.P.N., Douglas L. Hayden, M.A., David A. Schoenfeld, Ph.D., Philip W. Kantoff, M.D., and Joel S. Finkelstein, M.D.

The purpose of this study was to determine whether a gonadotropin-releasing hormone agonist would prevent osteoporosis in men with prostate cancer. Here 47 patients with advanced or recurrent prostate cancer without bone metastasis were assigned to receive either leuprolide alone or leuprolide and pamidronate combined. Those who completed the study consisted of 41 patients. After 48 weeks physicians found substantial differences in bone mineral density between the two types of hormone therapies administered. Patients receiving leuprolide alone averaged a bone mineral density decrease of 3.3 percent in the lumbar spine, 2.1 percent in the trochanter, and 1.8 percent in the total hip. In contrast, patients treated with leuprolide and pamidronate experienced no significant bone mineral density changes at any skeletal site.


“Alternative Antiandrogens to Treat Prostate Cancer Relapse After Initial Hormone Therapy”
KOJIMA, SATOKO; SUZUKI, HIROYOSHI *; AKAKURA, KOICHIRO; SHIMBO, MASAKI; ICHIKAWA, TOMOHIKO; ITO, HARUO Journal of Urology. 171(2): 679-683, February 2004.

In this study 70 patients with advanced prostate cancer were treated with hormone therapy, androgen deprivation monotherapy, or maximum androgen blockade including surgical or medical castration combined with steroidal antiandrogen. Doctors discontinued antiandrogen stopped responding to treatments. Patients were then evaluated for withdrawal effects. Soon after doctors administered an alternative antiandrogen. At first line hormonal therapy 35.8 percent of patients exhibited an incidence of withdrawal, 8.0 percent at second line, and 0 percent at third line. An effective alternative in second line or third line hormone therapy is nonsteroidal antiandrogens.


“Hormone Therapy for Locally Advanced Prostate Cancer”
FOWLER, JACKSON E. JR. *; BIGLER, STEVEN A.; WHITE, PAIGE C.; DUNCAN, WILLIAM L. Journal of Urology. 168(2):546-549, August 2002.

This study evaluated 208 patients with locally advanced prostate cancer who were treated between February 1991 and November 2000 with gonadal androgen ablation or gonadal androgen ablation and an antiandrogen. Patients had an average PSA level of 46ng/mL. Doctors tracked them at approximately 78 months and conducted observations at 46 months. Fourteen patients (7 percent) died of causes related to cancer and 71 patients (34 percent) died of associative diseases. The rate of cause-specific survival was heavily influenced by having a Gleason score less than 8 or greater than 8. At five years all cause survival was 59 percent and at eight years it was 41 percent. Complications from the primary tumor developed in 13 patients (6 percent) and included obstructive symptoms, which required a transurethral prostate resection, a ureteral obstruction, or persistent hematuria. Complications from treatment developed in four patients and included flutamide hepatotocicity and a hip fracture.

 
 
 
 

 
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